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(69) published the retrospective cohort study performed in 644,183 patients aged over 65 years who had been receiving acetaminophen usual dosage acetaminophen codeine dosage acetaminophen er 650 mg acetaminophen paracetamol (at daily doses: 3 g) and/or traditional NSAIDs (with or without a proton pump inhibitor) for 6 years . The risk of hospitalization due to gastrointestinal events (ulceration, perforation, bleeding from the upper or lower segment of the digestive tract) appeared to be two-fold higher in the case of taking paracetamol in combination with traditional NSAIDs as compared to NSAIDs used infant acetaminophen new dosage chart acetaminophen mechanism acetaminophen baby acetaminophen in monotherapy . The authors of that study (69), as well as other researchers analyzing the problem of interaction between paracetamol and NSAIDs (8), explain the results in relation to the additional COX-1 inhibition acetaminophen caused by paracetamol .
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